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Oral Steroids

Oral Anabolic Steroids

Oral steroids are preferred by individuals who want quick results. This is because oral steroids are in ready form and once they are ingested they immediately undergo the so-called first-pass metabolism and enter the bloodstream to exert their anabolic effects. Injectable steroids, particularly those that have esters, cannot be readily used by the body because the ester chain should be cut off first by hepatic enzymes before they can be active. Another advantage of oral steroids is their shorter half-lives, which means their metabolites do not stay in the system for long. This property is what makes oral steroids the choice by most athletes who undergo anti-doping screening. Among the most popular oral steroids are Anadrol, Dianabol and Anavar.

Oral steroids, however, can pose drawbacks to users. One of the common complaints with oral steroids is that they are stressful to the liver, particularly those which are c-17 alpha-alkylated. The 17 alkylation is added to improve the bioavailability of oral steroids. Without this chemical alteration, drugs may not be able to survive the first-pass metabolism of the liver, and thus may not be able to exert anabolic effects.

The liver fulfills vital functions in the body, including storage of important nutrients like glycogen and clearance of waste products (detoxification). Oral steroids can negatively affect the liver’s ability to carry out these functions.

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